Paraneoplastic Necrotizing Myopathy Associated With Ovarian Adenocarcinoma.
- Author:
Hye Mi LEE
1
;
Ji Sun KIM
;
Minjik KIM
;
Sung Hoon KANG
;
Jin Hwa HONG
;
Sung Hye PARK
;
Ji Hyun KIM
Author Information
1. Department of Neurology, Korea University College of Medicine, Seoul, Korea. jhkim.merrf@gmail.com
- Publication Type:Case Report
- Keywords:
Paraneoplastic myopathy;
Necrotizing myopathy;
Ovarian adenocarcinoma
- MeSH:
Adenocarcinoma*;
Drug Therapy;
Female;
Humans;
Muscular Diseases*;
Myalgia;
Necrosis;
Neurologic Manifestations;
Quadriceps Muscle
- From:Journal of the Korean Neurological Association
2014;32(1):34-37
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We describe here a case of female patient who presented with mild proximal weakness, myalgia, and markedly elevated CPK, which could be ascribed to paraneoplastic necrotizing myopathy in association with ovarian adenocarcinoma. A histologic examination of the vastus lateralis muscle showed necrosis of muscle fibers without inflammatory cell infiltration. Her neurologic symptoms improved following tumor resection and systemic chemotherapy. Paraneoplastic necrotizing myopathy may be a presenting manifestation of malignancy, and early recognition and prompt treatment are crucial for the clinical improvement.
