Expression of Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) in Pancreatic Ductal Adenocarcinoma.
- Author:
Mi Jin GU
1
;
Young Kyung BAE
;
Joon Hyuk CHOI
Author Information
1. Department of Pathology, Holy Trinity Hospital.
- Publication Type:Original Article
- Keywords:
Pancreas;
Duct;
Adenocarcinoma;
MMP-2;
TIMP-2
- MeSH:
Adenocarcinoma*;
Lymph Nodes;
Matrix Metalloproteinase 2*;
Neoplasm Metastasis;
Pancreas;
Pancreatic Ducts*;
Stromal Cells;
Tissue Inhibitor of Metalloproteinase-2*
- From:Korean Journal of Pathology
2004;38(2):73-78
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Matrix metalloproteinase-2 (MMP-2) is known to be one of the key molecules for tumor invasion and metastasis. MMP-2 activity is modulated through interaction with the tissue inhibitor of metalloproteinase-2 (TIMP-2). The purpose of this study was to evaluate the expression of MMP-2 and TIMP-2 in pancreatic ductal adenocarcinoma. METHODS: Using immunohistochemical staining, we investigated the expression of MMP-2 and TIMP-2 in 30 pancreatic ductal adenocarcinomas and 10 normal pancreas. RESULTS: MMP-2 expression was present in tumor cells in 11 cases, and in stromal cells in 24 cases, out of 30 carcinomas. MMP-2 expression of tumor cells was significantly higher in poorly differentiated adenocarcinomas than in well/moderately differentiated adenocarcinomas, and in cases with vascular invasion than in cases without. MMP-2 expression was stronger in the marginal areas than in the central area of the tumor. TIMP-2 expression was detected in the tumor and stromal cells of all carcinomas. MMP-2 and TIMP-2 expression had no significant correlation with tumor size, lymph node metastasis, or TNM stage. MMP-2 expression was not correlated with TIMP-2 expression. CONCLUSIONS: These results suggest that MMP-2 expression may play an important role in the invasive property of pancreatic ductal adenocarcinoma, whereas TIMP-2 expression increases as a reaction to invasion.
