Minimal Deviation Adenocarcinoma, Mucinous Type, of the Uterine Cervix: Report of a Case with Extensive Metastasis to the Uterine Corpus and Bilateral Adnexae.
- Author:
Eundeok CHANG
1
;
Eunjung LEE
;
Kyoungmee KIM
;
Okran SHIN
;
Youngmi KU
;
Heejung AN
;
Changsuk KANG
Author Information
1. Department of Clinical Pathology, The Catholic University of Korea, College of Medicine, Uijongbu, Korea. ejlpath@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Adenocarcinoma, Mucinous;
Cervix
- MeSH:
Adenocarcinoma*;
Adenocarcinoma, Mucinous*;
Adult;
Cervix Uteri*;
Cystadenoma, Mucinous;
Fallopian Tubes;
Female;
Humans;
Keratin-20;
Keratin-7;
Neoplasm Metastasis*;
Oligonucleotide Array Sequence Analysis;
Ovary
- From:Korean Journal of Pathology
2004;38(2):121-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
Minimal deviation adenocarcinoma is an extremely well differentiated variant of cervical adenocarcinoma, and is frequently misdiagnosed due to its benign-looking histopathological features. A 38-year-old woman was diagnosed as having had a minimal deviation adenocarcinoma in the cervix, metastasizing to the uterine body and bilateral adnexae. She had a history of right salpingo-oophorectomy 3 years ago, and was diagnosed as having a mucinous cystadenoma. Histologically, the tumor cells were so well-differentiated that they appeared to be almost the same as those of the non-neoplastic cervical glands. Similar glands were found in both ovaries and in the left fallopian tube. PAS staining showed a negative or apical positive pattern in the endocervical-like glands. Immunohistochemical studies for CEA, ER/PR, cytokeratin 20, and p53 were negative, but positive for cytokeratin 7. The HPV DNA microarray test was negative. Clinically, this proved to be an advanced, biologically aggressive disease.
