A Study of Immunohistochemical Evaluation of bcl-2 Protein and p53 Protein Expression in Epithelial Ovaria Cancers.
- Author:
Sang Joon CHOI
1
;
Young Ho KIM
;
Gyung Chul RHU
;
Sei Jun HAN
;
Chang Hun SONG
;
Hyuk JUNG
;
Sung Chul LIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
Epithelial ovarian cancer;
bcl-2;
p53
- MeSH:
Apoptosis;
Humans;
Immunohistochemistry;
Ovarian Neoplasms;
Prognosis
- From:Korean Journal of Obstetrics and Gynecology
1997;40(11):2464-2472
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bcl-2 and p53, two proteins, have implicated in apoptosis and among them p53 is known as adverse prognostic factor in a number of tumors. But it is variable in different tissues whether bcl-2 expression and its role are related in the prognosis. The present study was aimed to find the role of bcl-2 and p53 in prognosis of epithelial ovarian cancer. We examined 32 epithelial ovarian cancer specimens of different histologic types and stages by immunohistochemical staining. Bcl-2 protein expression was found in 11/32 epithelial ovarian cancers and it was related in survival(p=0.0038) and p53 accumulation was found in 17/32 epithelial ovarian cancers but it was not rrelated in survival(p=0.0717). But bcl-2 expression and p53 accumulation were not related to the FIGO stages(p>0.05). The analysis of the postoperative course of 32 patients showed that survival depended on the FIGO stages(p=0.001 2) and the histologic type(p=0.009). However, bcl-2 immunohistochemistry identified a subgroup of patients with p53 and bcl-2 positive carcinomas who had not a statistically better outcome(p=0.082) than patients with p53 positive and bcl-2 negative carcinomas. Thus our observations point to different molecular alterations possibly underlying phenotypic diversity of ovarian carcinomas and provide clues for a better understanding of tumor progression in these neoplasms.
