c-erb B2 and p53 Overexpression in Presence of Human Papilloma Virus Type 16/18 Infection in Carcinomas of the Uterine Cervix: Genesis and Clinicopathologic Analysis.
- Author:
Sang Min LEE
1
;
Cheon Jun LEE
;
Won Gue KIM
;
Un Dong PARK
;
Man Ha HUH
;
Bang HUR
;
Moo Youn CHO
;
In Cheol JEONG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
c-erb B2;
p53;
Human papilloma virus;
Carcinomas of the uterine cervix
- MeSH:
Cervix Uteri*;
Female;
Humans*;
Lymph Nodes;
Mitosis;
Neoplasm Metastasis;
Papilloma*
- From:Korean Journal of Obstetrics and Gynecology
1997;40(11):2482-2491
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The 43 cases of the primary uterine cervical carcinoma were analyzed for HPV type 16/18 infection and also analyzed for overexpression of p53 and c-erb B2 oncoprotein to evaluate theirs oncogenic and clinicopathologic relationships. HPV type 16/18 infection was examined by polymerase chain reaction(PCR) and the overexpression of p53 and c-erb B2 protein by using immunohistochemical method. The results were as follow: 1. The HPV infection rate in primary uterine cervical carcinomas was 83.7% respectively.The standard clinicopathologic characteristics(age, histologic type, koilocytosis, mitosis, clinical stage, tumor size, cervical invasion depth, lymph node metastasis, parametrial invasion) were nat significantly correlated with HPV type 16/18 infectivity. 2. The overexpression rate of p53 protein was 72.1% and there was no Significant correlation between expression of p53 protein and the Clinicopathologic characteristics. 3. The overexpression of c-erb B2 oncoprotein was 44.2% and there was no significant correlation between the overexpression of c-erb B2 oncoprotein and the clinicopathologic characteristics. 4. There was no significant correlation between HPV type 16/18 infection and overexpression of p53 and c-erb B2 oncoprotein.
