Roles of Matrix Metalloproteinases and Their Targets in Epileptogenesis and Seizures.
- Author:
Hiroyuki MIZOGUCHI
1
;
Kiyofumi YAMADA
Author Information
1. Futuristic Environmental Simulation Center, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
- Publication Type:Review
- Keywords:
Matrix metalloproteinase;
Tissue inhibitor of metalloproteinase;
Epilepsy;
Seizure;
Nerve growth factors
- MeSH:
Cell Adhesion;
Epilepsy;
Extracellular Matrix Proteins;
Intercellular Signaling Peptides and Proteins;
Long-Term Potentiation;
Matrix Metalloproteinases;
Metalloproteases;
Models, Animal;
Nerve Growth Factors;
Receptors, Neurotransmitter;
Seizures
- From:Clinical Psychopharmacology and Neuroscience
2013;11(2):45-52
- CountryRepublic of Korea
- Language:English
-
Abstract:
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which together regulate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathological conditions. Recent studies have suggested that prolonged seizures are associated with high MMP levels in serum and neural tissues, and certain extracellular macromolecule targets may influence the pathogenesis of epilepsy and seizure. In this review, we discuss the roles of MMP activation in animal models of epilepsy.
