Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury.
- Author:
Sodam JUNG
1
;
Sang Hoon KIM
;
Jang Won SOHN
;
Ho Joo YOON
;
Dong Ho SHIN
;
Young Koo JEE
;
Sang Heon KIM
Author Information
- Publication Type:Original Article
- Keywords: Antitubercular agents; Drug-induced liver injury; Interleukin-10; Transforming growth factor beta1; Genetic polymorphism
- MeSH: Antitubercular Agents; Cytokines; Drug-Induced Liver Injury; Genotype; Hepatitis; Humans; Interleukin-10*; Liver*; Polymorphism, Genetic*; Polymorphism, Single Nucleotide; Transforming Growth Factor beta1
- From:Allergy, Asthma & Respiratory Disease 2017;5(1):41-46
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of medications. Previously, IL-10 gene polymorphism has been reported to be associated with diclofenac-induced hepatitis. In this study, we aimed to investigate the associations between genetic polymorphisms of immune-regulating cytokines (IL-10 and TGF-β1) with antituberculosis drugs (ATD)-induced liver injury. METHODS: We enrolled 80 patients with ATD-induced liver injury and 238 ATD-tolerant controls. Two single nucleotide polymorphisms (SNP) of IL-10 (-1082A>G, rs1800896; -819T>C, rs1800871) and one promoter SNP of TGF-β1 gene (-509C>T, rs1800469) were genotyped in both groups. Genotype frequencies of these SNPs were compared between case and control groups. RESULTS: In 2 promoter SNPs of IL-10 gene, there was no significant difference of genotype frequencies between patients with ATD-induced liver injury and controls. In addition, the genotype frequency of TGF-β1 -509C>T SNP in ATD-induced liver injury patients were not different from those of controls. CONCLUSION: In conclusion, there was no significant association between IL-10 and TGF-β1 gene polymorphisms and ATD-induced liver injury. These findings suggest that IL-10 and TGF-β1 do not play important role in the development of ATD-induced liver injury.
