Acute generalized exanthematous pustulosis presumed to be caused by acetaminophen.
- Author:
Hyeong Woo KIM
1
;
Yong Sun CHOI
;
Jung Ho WON
;
Jae Min LEE
;
Jin Young HEO
;
Jung Ah CHOI
;
Mi Jung OH
Author Information
- Publication Type:Case Report
- Keywords: Acute generalized exanthematous pustulosis; Acetaminophen; Drug eruption
- MeSH: Acetaminophen*; Acute Generalized Exanthematous Pustulosis*; Aged; Anti-Bacterial Agents; Back Pain; Biopsy; C-Reactive Protein; Drug Eruptions; Eosinophils; Erythrocytes; Female; Fever; Humans; Leukocytosis; Rare Diseases; Skin
- From:Allergy, Asthma & Respiratory Disease 2017;5(1):52-55
- CountryRepublic of Korea
- Language:Korean
- Abstract: Acute generalized exanthematous pustulosis (AGEP) is a severe and rare disease usually related to drug eruption. AGEP is induced by drugs in over 90% of cases with antibiotics being the most common. It is characterized by a fever and a pustular eruption on erythematous skin with acute onset and without follicular localization. Acetaminophen is commonly used as an antipyretic and analgesic. Acetaminophen has been reported to be an uncommon cause of AGEP. We report a 79-year-old woman presenting with fever and erythematous maculopapular eruptions on the trunk with sterile pustules arising upon the use of acetaminophen for back pain. Leukocytosis and elevated C-reactive protein levels were noted on the laboratory examination. The histopathological examination of the skin biopsy specimen showed intraepidermal pustule formation with superficial perivascular lymphocytic infiltration, including eosinophils, and extensive red blood cell extravasation. The lesions were resolved with discontinuation of acetaminophen and use of systemic corticosteroid. We report a case of AGEP probably caused by acetaminophen.
