Clinical Course of Eosinophilic Bronchitis in Children.
10.7581/pard.2012.22.3.273
- Author:
Yoon Hee KIM
1
;
Jong Deok KIM
;
Hyun Bin PARK
;
Jiyoung BAEK
;
Kyung Won KIM
;
Myung Hyun SOHN
;
Kyu Earn KIM
Author Information
1. Department of Pediatrics, Institute of Allergy, Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. jy10078@naver.com
- Publication Type:Original Article
- Keywords:
Asthma;
Child;
Chronic cough;
Eosinophilic bronchitis;
Prognosis;
Rhinosiusitis
- MeSH:
Adrenal Cortex Hormones;
Adult;
Airway Obstruction;
Asthma;
Bronchitis;
Child;
Cough;
Eosinophils;
Humans;
Inflammation;
Nitric Oxide;
Oscillometry;
Prognosis;
Respiratory Function Tests;
Spirometry;
Sputum
- From:Pediatric Allergy and Respiratory Disease
2012;22(3):273-281
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: It has been identified that eosinophilic bronchitis (EB) in adults can progress to asthma or fixed airway obstruction. In the present study, we evaluated the clinical course and prognosis of EB in children and their relationship with accompanying rhinosinusitis. METHODS: A total of 55 children with EB followed up for over than a year after the diagnosis were enrolled for the present study. We classified the subjects into two groups according to the prognosis and the presence of rhinosinusitis, respectively, and compared them with respect to clinical characteristics, eosinophil percentage in induced sputum, fractional exhaled nitric oxide (FeNO) and pulmonary function test. The poor prognostic group was defined as the children with asthma or asthma-like symptoms, or persistent or recurrent chronic cough in the long-term follow-up. RESULTS: The poor prognosis was achieved in 12 children (22%), and 3 children (5%) amongst them were diagnosed with asthma. There were no significant differences in clinical characteristics, eosinophil percentages in induced sputum, FeNO, spirometry and IOS according to the prognosis and the presence of rhinosinusitis. Additionally, the children with rhinosinusitis did not show any poorer outcome than those without rhinosinusitis. CONCLUSION: There were some limitations of this study for which the relationship between EB and rhinosinusitis in children was evaluated. However, in case of either poor short-term response to inhaled corticosteroids or elevated eosinophilic inflammation in airways or abnormal airway reversibility in impulse oscillometry, the long-term prognosis of EB in children needs to be considered, regardless of the presence of rhinosinusitis.
