A Case of Cryptococcal Spondylitis Following Allogeneic Hematopoietic Stem Cell Transplantation.
- Author:
Yoon Ho KO
1
;
Dong Jun LIM
;
Seong Su LEE
;
Yu Kyung CHO
;
Dong Gun LEE
;
Jung Hyun CHOI
;
Yoo Jin KIM
;
Chang Ki MIN
;
Dong Wook KIM
;
Jeong Mi PARK
;
Chun Choo KIM
;
Wan Shik SHIN
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cryptococcus;
Spondylitis;
Bone Marrow Transplantation
- MeSH:
Adult;
Amphotericin B;
Bacteria;
Biopsy;
Bone Marrow Transplantation;
Cerebrospinal Fluid;
Cryptococcosis;
Cryptococcus;
Cyclosporine;
Extremities;
Female;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation*;
Hematopoietic Stem Cells*;
Hodgkin Disease;
Humans;
Leukemia;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Low Back Pain;
Meningitis;
Sarcoidosis;
Spinal Puncture;
Spondylitis*;
Tuberculosis;
Yeasts
- From:Korean Journal of Infectious Diseases
2001;33(4):298-301
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Skeletal cryptococcosis is an uncommon infection. Cryptococcus is a common cause of meningitis and infects 7~10% of patients with AIDS. As well as AIDS, the infection may be seen in association with leukemia, lymphoma, Hodgkin's disease, sarcoidosis, tuberculosis and diabetes, also in patients on steroid medication. But there is no case report of skeletal cryptococcosis following allogeneic hematopoietic stem cell transplantation. A 40-year-old woman was admitted to the hospital because of low back pain. She had chronic myelogenous leukemia for 2 years and underwent allogeneic hematopoietic stem cell transplantation 8 months ago. She have been treated with steroid and cyclosporine orally because of chronic graft versus host disease. On examination she was afebrile and had posterior lower lumbar tenderness. But, she had no reduced strength of low extremities. Open biopsy was underwent. Histology demonstrated budding, round-to-oval, refractile yeast-like organisms within debris. The results of a lumbar puncture were unremarkable and cerebrospinal fluid culture failed to grow bacteria and yeast. The patient was treated with amphotericin B (1 gram) and AmBisome (2.8 gram) over 6 weeks. Three months after cessation of therapy, the patient was doing well.
