Effect of mucilage from yam on activation of lymphocytic immune cells.
- Author:
Cheol Min JANG
1
;
Dae Hyuk KWEON
;
Jong Hwa LEE
Author Information
- Publication Type:Original Article
- Keywords: Yam-mucilage; immunostimulation; lymphocyte proliferation; cytokine; functional food
- MeSH: Bifidobacterium; Concanavalin A; Cytokines; Dioscorea*; Functional Food; Immunization; Interleukin-6; Lymph Nodes; Macrophages; Panax; Tumor Necrosis Factor-alpha
- From:Nutrition Research and Practice 2007;1(2):94-99
- CountryRepublic of Korea
- Language:English
- Abstract: The immunostimulating activities of mucilage fraction from yam were investigated. The proliferation of BSA-primed lymph node cells was enhanced between 4.1- to 10.9-fold compare to control, when cultured with 1 to 25 microgram/mL of yam-mucilage fraction. It showed strong immunopotentiating activity than ginseng extract and as remarkable as Bifidobacterium adolescentis M101-4 known as a positive immunostimulator. Mitogenicity to lymph node cells was fully induced by concanavalin A and lipopolysaccharide. The proliferation of splenocytes and Peyer's patch cells was enhanced between 5.0- to 14.1-fold and 2.4- to 6.4-fold, respectively, when cultured with 1 to 25 microgram/mL of yam-mucilage fraction. It enhanced the production of cytokines such as tumor necrosis factor-alpha and IL-6 in the culture of RAW 264.7 macrophage cells. In the culture of lipopolysaccharide-stimulated RAW 264.7 cells, production of cytokines was as similar as compared to controls. In unstimulated RAW 264.7 cells, both tumor necrosis factor-alpha and IL-6 production were enhanced between 15.6- to 60.1-fold and 2.3- to 9.1-fold, respectively. Mucilage fraction from yam is expected to be a safe immunopotentiator to maintain the host immunity and develop a physiologically functional food.
