Hypoglycemic and hypolipidemic effects of Saururus chinensis Baill in streptozotocin-induced diabetic rats.
- Author:
Ji Yeon HWANG
1
;
Jian ZHANG
;
Min Jung KANG
;
Soo Kyung LEE
;
Hyun A KIM
;
Jong Jin KIM
;
Jung In KIM
Author Information
- Publication Type:In Vitro ; Original Article
- Keywords: Saururus chinensis Baill; glucose; cholesterol; triglyceride; streptozotocin
- MeSH: alpha-Glucosidases; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus; Diet; Diet, High-Fat; Glucose; Humans; Injections, Intravenous; Intestinal Mucosa; Male; Models, Animal; Rats*; Saururaceae*; Streptozocin; Triglycerides
- From:Nutrition Research and Practice 2007;1(2):100-104
- CountryRepublic of Korea
- Language:English
- Abstract: Saururus chinensis Baill was reported to inhibit alpha-glucosidase in vitro and flatten postprandial increase in blood glucose in streptozotocin (STZ)-induced diabetic rats. We studied the effect of chronic consumption of S. chinensis Baill on blood glucose and lipid profile in STZ-induced diabetic male rats fed high fat diet. Male rats weighing 100-120 g were fed 30% fat diet with and without 10% freeze-dried leaves of S. chinensis Baill for 7 weeks after 1 week of adaptation. The rats were rendered diabetic by intravenous injection of STZ (60 mg/kg) after 6-week feeding of the assigned diets. At 1 week after the injection, the rats were sacrificed after an overnight fast. Plasma glucose (380.2 +/- 14.4 mg/dL), total cholesterol (93.9 +/- 7.9 mg/dL) and triglyceride levels (123.6 +/- 7.5 mg/dL) of the S. chinensis Baill group were significantly lower than those of the control group (418.1 +/- 12.0 mg/dL, 119.9 +/- 9.4 mg/dL, 152.0 +/- 10.3 mg/dL, respectively, p<0.05). Chronic consumption of S. chinesis Baill significantly decreased maltase activity of the small intestinal mucosa (120.1 +/- 8.7 U/g protein) compared with the control group (96.8 +/- 7.0 U/g protein, p<0.05). These results suggest that S. chinensis Baill have hypoglycemic and hypolipidemic effects by inhibiting alpha-glucosidase activity in the animal model of diabetes mellitus.
