Expression of the mutant p53 gene in the carcinoma of the cervix uteri.
- Author:
Kyung Ik KWON
;
Tae Sung LEE
;
Jiung Ho RHEE
;
Soon Do CHA
;
Sang Sook LEE
;
Young Wook SUH
- Publication Type:Original Article
- Keywords:
p53;
Carcinoma of the Cervix
- MeSH:
Carcinoma, Large Cell;
Cervix Uteri*;
Disease Progression;
Female;
Genes, p53*;
Prognosis;
Recurrence
- From:Korean Journal of Gynecologic Oncology and Colposcopy
1994;5(4):23-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The nuclear accumulation of p53 protein is known to correspond with mutation of p53 tumor supressor gene. To investigate the relationsbip between clinico-pathologic features and expression of p53 mutations, 65 cases of primary cervical carcinoma were analysed by an immunohistochemieal method using monoclonal antibody of p53. Immunostaining demonstrated varioua nuclear stinings of cancer cells in 48.4% of squamous cell carcinoma(51.9% in large cell carcinoma and 25.0% in small cell carcinomas) and 23.5% of adenocarcinoma(p<0.05) No differences in clinical stage and p53 positivity were found. There was no significant correlation between p53 positive cases and status of recurrence. This data suggests that p53 protein is not correlated with the disease progression and prognosis.
