Correlation between Semiquantitative Myocardial Perfusion Score and Absolute Myocardial Blood Flow in 13N-Ammonia PET.
- Author:
Byeong Il LEE
1
;
Kye Hun KIM
;
Jung Young KIM
;
Su Jin KIM
;
Jae Sung LEE
;
Jung Joon MIN
;
Ho Chun SONG
;
Hee Seung BOM
Author Information
1. Department of Nuclear Medicine, Chonnam National University Hospital, Korea. hsbom@jnu.ac.kr
- Publication Type:Original Article
- Keywords:
myocardial blood flow;
perfusion;
cardiac PET;
13N-ammonia
- MeSH:
Coronary Artery Disease;
Female;
Humans;
Male;
Myocardium;
Perfusion*
- From:Nuclear Medicine and Molecular Imaging
2007;41(3):194-200
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: 13N-ammonia is a well known radiopharmaceutical for the measurement of a myocardial blood flow (MBF) non-invasively using PET-CT. In this study, we investigated a correlation between MBF obtained from dynamic imaging and myocardial perfusion score (MPS) obtained from static imaging for usefulness of cardiac PET study. METHODS: Twelve patients (11 males, 1 female, 57.9+/-8.6 years old) with suspicious coronary artery disease underwent PET-CT scan. Dynamic scans (6 min: 5 sec X 12, 10 sec X 6, 20 sec X 3, and 30 sec X 6) were initiated simultaneously with bolus injection of 11 MBq/kg 13N-ammonia to acquire rest and stress image. Gating image was acquired during 13 minutes continuously. Nine-segment model (4 basal walls, 4 mid walls, and apex) was used for a measurement of MBF. Time activity curve of input function and myocardium was extracted from ROI methods in 9 regions for quantification. The MPS were evaluated using quantitative analysis software. To compare between 20-segment model and 9-segment model, 6 basal segments were excluded and averaged segmental scores were used. RESULTS: There are weak correlation between MBF (rest, 0.18-2.38 ml/min/g; stress, 0.40-4.95 ml/min/g) and MPS (rest 22-91%, stress, 14-90%), however the correlation coefficient between corrected MBF and MPS in rest state was higher than stress state (rest r=0.59; stress r=0.80). As a thickening increased, correlation between MBF and MPS also showed good correlation at each segments. CONCLUSIONS: Corrected and translated MPS as its characteristics using 13N-ammonia showed good correlation with absolute MBF measured by dynamic image in this study. Therefore, we showed MPS is one of good indices which reflect MBF. We anticipate PET-CT could be used as useful tool for evaluation of myocardial function in nuclear cardiac study.
