Fine Needle Aspiration Cytology of Parathyroid Lesions.
- Author:
Ilyeong HEO
1
;
Sunhoo PARK
;
Chang Won JUNG
;
Jae Soo KOH
;
Seung Sook LEE
;
Hyesil SEOL
;
Hee Seung CHOI
;
Soo Youn CHO
Author Information
1. Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea. pathsycho@naver.com
- Publication Type:Original Article
- Keywords:
Parathyroid lesions;
Biopsy, fine-needle;
Cytology
- MeSH:
Biopsy, Fine-Needle*;
Chromatin;
Cytoplasm;
Goiter;
Humans;
Male;
Thyroid Gland
- From:Korean Journal of Pathology
2013;47(5):466-471
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: There has been an increase in the use of fine needle aspiration cytology (FNAC) for the diagnosis of parathyroid lesions (PLs). Differentiation between a thyroid lesion and a PL is not easy because of their similar features. We reviewed parathyroid aspirates in our institution and aimed to uncover trends in diagnostic criteria. METHODS: We selected 25 parathyroid aspirates (from 6 men and 19 women) confirmed surgically or immunohistochemically from 2006 to 2011. RESULTS: Major architectural findings of PLs include scattered naked nuclei, loose clusters, a papillary pattern with a fibrovascular core, tight clusters, and a follicular pattern. These architectures were commonly admixed with one another. Cytological features included anisokaryosis, stippled chromatin, a well-defined cell border, and oxyphilic cytoplasm. Eighteen of the 25 patients were diagnosed with PL using FNAC. Seven patients had been misdiagnosed with atypical cells (n=2), benign follicular cells (n=2), adenomatous goiter (n=2) and metastatic carcinoma (n=1) in FNAC. Using clinicoradiologic data, the sensitivity of the cytological diagnosis was 86.7%. The cytological sensitivity decreased to 50% without this information. CONCLUSIONS: FNAC of PL is easily confused with thyroid lesions. A combination of cytological parameters and clinical data will be required to improve the diagnostic sensitivity of PLs.
