Familial systemic lupus erythematosus in two Korean male siblings.
10.3345/kjp.2009.52.5.611
- Author:
Hyun Sik KANG
1
;
Hyun Ju OH
;
Young Ree KIM
;
Jae Wang KIM
;
Kyung Sue SHIN
Author Information
1. Department of Pediatrics, Cheju National University School of Medicine, Jeju, Korea. kyungsue@jeju.ac.kr
- Publication Type:Case Report
- Keywords:
Familial systemic lupus erythematosus;
Children;
Male;
Sibling;
Human leukocyte antige
- MeSH:
Autoantibodies;
Autoimmune Diseases;
Child;
Disease Susceptibility;
Genetic Predisposition to Disease;
Haplotypes;
Humans;
Leukocytes;
Lupus Erythematosus, Systemic;
Male;
Mothers;
Siblings
- From:Korean Journal of Pediatrics
2009;52(5):611-614
- CountryRepublic of Korea
- Language:English
-
Abstract:
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of a wide range of autoantibodies, resulting in tissue damage. Although the susceptibility to SLE has been attributed to complex interactions between genetic and environmental factors, the influence of a genetic predisposition to SLE is supported by observations of familial aggregations. Family studies have found that siblings with an SLE-affected relative have a 20-fold higher risk of developing SLE compared with the general population. Here, we present a rare case of two male siblings with SLE. The clinical, laboratory, and histopathological findings of these individuals showed the characteristic features of SLE. Human leukocyte antigen (HLA) typing revealed that the brothers and their mother shared the common HLA haplotype of DRB1*1501 and DQB1*0602, which is significantly associated with disease susceptibility in both family-based and casecontrol studies. This report provides an opportunity to reveal the role of genetic factors in the development of SLE.
