The effect of micro-macroporous biphasic calcium phosphate incorporated with polyphosphate on exophytic bone regeneration.
10.5051/jkape.2008.38.2.179
- Author:
Dong Hwan KIM
1
;
Young Hyuk KWON
;
Joon Bong PARK
;
Jong Hyuk CHUNG
;
Yeek HERR
Author Information
1. Department of Periodontology, School of Dentistry, Kyung Hee University, Korea. yherr@khu.ac.kr
- Publication Type:Original Article
- Keywords:
MBCP;
polyphosphate;
exophytic bone regeneration
- MeSH:
Animals;
Bone and Bones;
Bone Regeneration;
Calcium;
Hydroxyapatites;
Membranes;
Osteogenesis;
Skull;
Titanium
- From:The Journal of the Korean Academy of Periodontology
2008;38(2):179-190
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In this study, the effect of micro-macroporous biphasic calcium phosphate(MBCP) incorporated with inorganic polyphosphate for bone regeneration in the calvaria of rabbit was evaluated. MATERIALS AND METHODS: The procedure of guided bone regeneration was performed with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. Four animal groups were compared : 1) TR-ePTFE membrane for negative control group, 2) TR-ePTFE membrane filled with MBCP for positive control group, 3) TR-ePTFE membrane filled with MBCP soaked in 4% inorganic polyphosphate for experimental group I, and 4) TR-ePTFE membrane filled with MBCP soaked in 8% inorganic polyphosphate for experimental group II. RESULTS: 1. Negative control group showed the highest new bone formation at 16 weeks. 2. Positive control group showed the smallest new bone formation compared to other groups. 3. 8% inorganic polyphosphate induced more volume of bone formation, otherwise experimental group II did not show significant difference compared to negative control group. CONCLUSION: These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration, possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue.
