Which Patients Should We Follow up beyond 5 Years after Definitive Therapy for Localized Renal Cell Carcinoma?.
- Author:
Sang Hyub LEE
1
;
Hee Seo SON
;
Seok CHO
;
Sang Jin KIM
;
Dae Seon YOO
;
Seok Ho KANG
;
Sung Yul PARK
;
Jinsung PARK
;
Sung Goo CHANG
;
Seung Hyun JEON
Author Information
- Publication Type:Original Article
- Keywords: Renal cell carcinoma; Kidney; Neoplasms; Recurrence
- MeSH: Carcinoma, Renal Cell*; Humans; Kidney; Logistic Models; Multivariate Analysis; Nephrectomy; Proportional Hazards Models; Recurrence; Risk Factors
- From:Cancer Research and Treatment 2015;47(3):489-494
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Up to 10% of recurrences develop beyond 5 years after curative treatment of localized renal cell carcinoma (RCC). Clinicopathologic features were evaluated to determine which factors are associated with late recurrence. MATERIALS AND METHODS: A total of 753 patients were diagnosed with localized RCC from January 2000 to June 2008. We enrolled 225 patients who were treated surgically and had a minimal recurrence-free survival of 60 months. Patients who had recurrence beyond 5 years after nephrectomy were defined as the late recurrence group and the remaining patients as the recurrence-free group. Multivariate logistic regression analyses and the Cox proportional hazard model were used for determination of features associated with late recurrence. RESULTS: In multivariate analyses, age older than 60 (p=0.030), Fuhrman grade > or = 3 (p=0.042), and pT stage > or = pT2 (p=0.010) showed statistical association with late recurrence. The Cox proportional hazard model showed significant differences in recurrence-free survival when we classified the patients based on pT2 (p=0.007) and on patient age > or = 60 years (p=0.039). CONCLUSION: Patient age greater than 60 years, Fuhrman grade > or = 3, and tumor stage > or = pT2 are independent risk factors of recurrence more than 5 years after surgery in patients with RCC. Therefore, close lifelong follow-up is recommended for patients with these risk factors.
