Soluble CD93 in Serum as a Marker of Allergic Inflammation.
10.3349/ymj.2017.58.3.598
- Author:
Hye Jung PARK
1
;
Heejae HAN
;
Sang Chul LEE
;
Young Woong SON
;
Da Woon SIM
;
Kyung Hee PARK
;
Yoon Hee PARK
;
Kyoung Yong JEONG
;
Jung Won PARK
;
Jae Hyun LEE
Author Information
1. Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Allergy;
asthma;
biomarker;
inhaled corticosteroid;
soluble CD93
- MeSH:
Asthma;
Humans;
Hypersensitivity;
Inflammation*;
Rhinitis;
Urticaria
- From:Yonsei Medical Journal
2017;58(3):598-603
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation. MATERIALS AND METHODS: We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were serially followed-up. RESULTS: The serum sCD93 levels (ng/mL) in patients with exacerbated AR (mean±standard deviation, 153.1±58.4) were significantly higher than in patients without AR (132.2±49.0) or with stable AR (122.3±42.1). Serum sCD93 levels in exacerbated CSU (169.5±42.8) were also significantly higher than those in non-CSU (132.4±51.6) and stable CSU (122.8±36.2). This trend was also seen in BA. Serum levels in patients with ICS-naïve BA (161.4±53.1) were significantly higher than those in healthy controls without BA (112.2±30.8), low- and medium-dose ICS users. Serum sCD93 levels in high-dose ICS users (72.2±20.6) were significantly lower than those in low- and medium-dose users. The serum sCD93 levels in steroid-naïve patients with BA (195.1±72.7) decreased after ICS use for 4 weeks (134.4±42.8) and 8 weeks (100.7±13.4), serially. CONCLUSION: Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU, AR, and asthma. ICS use significantly diminished serum sCD93 levels in steroid-naïve patients with BA. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation.
