The Effectiveness of Combined Imipramine and Desmopressin in the Treatment of Enuresis.
- Author:
Sung Jin KIM
1
;
Won Seok KIM
;
Jae Yong CHUNG
Author Information
1. Department of Urology, Sanggye Paik Hospital, College of Medicine, InJe University, Seoul, Korea. chung90@sanggyepaik.or.kr
- Publication Type:Original Article
- Keywords:
Enuresis;
Imipramine;
Desmopressin;
Combined therapy
- MeSH:
Child;
Deamino Arginine Vasopressin*;
Enuresis*;
Humans;
Imipramine*;
Recurrence
- From:Korean Journal of Urology
2001;42(11):1159-1162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effectiveness of combined imipramine and desmopressin in the treatment of enuretic patients who did not respond to imipramine. MATERIALS AND METHODS: Initially 83 children were treated with imipramine, as a primary treatment for 4 weeks. To 38 patients who did not respond to imipramine, low-dose desmopressin were additionally given per os. During the study, the patients were divided into three categories; 1) complete responder with 0-1 wet nights per week, 2) intermediate responders with 2-3 wet nights per week and 3) non-responders with more than three wet nights per week. RESULTS: The response rate of combined imipramine and desmopressin was 73.7% (28/38) and 11 patients out of 28 patients showed recurrence after the discontinuation of medication. No serious side effects were observed. CONCLUSIONS: Combined therapy was effective in enuretic children who did not respond to imipramine treatment.
