Unexpected Complication of Intravenous Recombinant Tissue Plasminogen Activator Thrombolysis in a Patient with Acute Ischemic Stroke: Aortic Dissection.
- Author:
Kwang Wook JO
1
;
Ik Seong PARK
;
Young Doo KIM
;
Seong Rim KIM
Author Information
1. Department of Neurosurgery, Bucheon St. Mary's Hospital, The Catholic University of Korea. twinpapa@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Aortic dissection;
Stroke;
Thrombolysis;
Tissue plasminogen activator
- MeSH:
Aged;
Aorta;
Cardiopulmonary Resuscitation;
Constriction, Pathologic;
Cyanosis;
Diabetes Mellitus;
Emergencies;
Female;
Heart Arrest;
Hemiplegia;
Hemorrhage;
Humans;
Hypertension;
Lung;
Middle Cerebral Artery;
Perfusion;
Pericardial Effusion;
Stroke;
Thorax;
Tissue Plasminogen Activator
- From:Korean Journal of Cerebrovascular Surgery
2009;11(4):204-206
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report here on a case of acute aortic dissection after intravenous tissue plasminogen activator (t-PA) administration in a patient with acute ischemic stroke. A 75-year-old woman with a history of hypertension and diabetes mellitus presented with left hemiplegia and a decreased mentality. The admission studies revealed severe stenosis of the right middle cerebral artery and decreased cerebral perfusion. Initial chest radiography showed hypertensive cardiovascular changes and increased interstial markings on both lung fields. Cyanosis and cardiac arrest occurred 80 minutes after intravenous t-PA administration. Emergency cardiopulmonary resuscitation was done and chest CT showed a dissection involving the whole aorta and pericardial effusion due to bleeding. In spite of our earnest efforts, the patient died. It should be kept in mind that aortic dissection can occur after intravenous t-PA administration and an early clinical suspicion and diagnosis is needed to avoid this devastating complication.
