Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas.
10.4132/KoreanJPathol.2014.48.5.346
- Author:
Min Jeong SONG
1
;
Joon Seon SONG
;
Jong Lyel ROH
;
Seung Ho CHOI
;
Soon Yuhl NAM
;
Sang Yoon KIM
;
Sung Bae KIM
;
Sang wook LEE
;
Kyung Ja CHO
Author Information
1. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kjc@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Cancer, radiation induced;
Head and neck neoplasms;
Sarcoma;
Mdm2 protein, human;
Tumor suppressor protein p53
- MeSH:
Diagnosis;
Head and Neck Neoplasms;
Head*;
Neck*;
Neoplasms, Radiation-Induced;
Sarcoma*;
Tumor Suppressor Protein p53
- From:Korean Journal of Pathology
2014;48(5):346-350
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas. METHODS: We studied the immunohistochemical expression of Mdm2 and p53 of 8 RISs. The intervals between radiation therapy and diagnosis of secondary sarcomas ranged from 3 to 17 years. RESULTS: Mdm2 expression was more common in de novo sarcomas than RISs (75% vs 37.5%), and p53 expression was more common in RISs than in de novo cases (75% vs 37.5%). While half of the RISs were Mdm2(-)/p53(+), none of de novo cases showed such combination; while half of de novo sarcomas were Mdm2(+)/p53(-), which are a candidate group of Mdm2 inhibitors, only 1 RIS showed such a combination. Variable immunoprofiles observed in both groups did not correlate with tumor types, except that all of 2 myxofibrosarcomas were Mdm2(+)/p53(+). CONCLUSIONS: In conclusion, we speculated that both radiation-induced and de novo sarcomagenesis are not due to a unique genetic mechanism. Mdm2-expression without p53 overexpression in 1 case of RIS decreases the future possibility of applying Mdm2 inhibitors on a subset of these difficult tumors.
