Epidural Infusion of Morphine and Levobupivacaine through a Subcutaneous Port for Cancer Pain Management.
10.3344/kjp.2014.27.2.139
- Author:
Bong Ha HEO
1
;
Tae Hee PYEON
;
Hyung Gon LEE
;
Woong Mo KIM
;
Jeong Il CHOI
;
Myung Ha YOON
Author Information
1. Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea. kimwm@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
cancer pain;
efficacy;
epidural catheter;
port;
side effects
- MeSH:
Analgesia;
Analgesia, Epidural;
Analgesics;
Catheterization;
Catheters;
Drug Delivery Systems;
Humans;
Injections, Subcutaneous;
Korea;
Medical Records;
Morphine*;
Nausea;
Pain Management*;
Paresthesia;
Retrospective Studies;
Vomiting;
Weights and Measures
- From:The Korean Journal of Pain
2014;27(2):139-144
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: To manage intractable cancer pain, an alternative to systemic analgesics is neuraxial analgesia. In long-term treatment, intrathecal administration could provide a more satisfactory pain relief with lower doses of analgesics and fewer side-effects than that of epidural administration. However, implantable drug delivery systems using intrathecal pumps in Korea are very expensive. Considering cost-effectiveness, we performed epidural analgesia as an alternative to intrathecal analgesia. METHODS: We retrospectively investigated the efficacy, side effects, and complications of epidural morphine and local anesthetic administration through epidural catheters connected to a subcutaneous injection port in 29 Korean terminal cancer patients. Patient demographic data, the duration of epidural administration, preoperative numerical pain rating scales (NRS), side effects and complications related to the epidural catheterization and the drugs, and the numerical pain rating scales on the 1st, 3rd, 7th and 30th postoperative days were determined from the medical records. RESULTS: The average score for the numerical pain rating scales for the 29 patients decreased from 7 +/- 1.0 at baseline to 3.6 +/- 1.4 on postoperative day 1 (P < 0.001). A similar decrease in pain intensity was maintained for 30 days (P < 0.001). Nausea and vomiting were the most frequently reported side effects of the epidural analgesia and two patients (6.9%) experienced paresthesia. CONCLUSIONS: Epidural morphine and local anesthetic infusion with a subcutaneous pump seems to have an acceptable risk-benefit ratio and allows a high degree of autonomy to patients with cancer pain.
