Coagulation Status Changes during Progressive Hemodilution.
10.4097/kjae.1997.33.5.918
- Author:
Young Soon CHOI
;
Woo Jae JOUN
;
Gaab Soo KIM
;
Tae Soo HAHM
;
Chung Su KIM
;
Baek Hyo SHIN
- Publication Type:In Vitro ; Original Article
- Keywords:
Blood, coagulation, hemodilution, thrombelastography
- MeSH:
Blood Coagulation;
Hemodilution*;
Humans;
Thrombelastography
- From:Korean Journal of Anesthesiology
1997;33(5):918-922
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Hemodilution reduces the concentration of clotting factors in blood and this may induce some degree of impairment of coagulation. But there are some evidence that hemodilution may induce a hypercoagulable state. The goal of this study is to investigate the changes of coagulation status during progressive hemodilution. METHODS: Whole Blood was diluted by 10% increment to 80% with 0.9% normal saline. At each 10% dilution blood coagulation status was analysed using thrombelastography (TEG) and was compared with that of an undiluted control specimen obtained concurrently from the same patients. RESULTS: Hemodilutions up to 40% decrease r and K times and increase values of MA and angle. Hemodilutions more than 70% increase r and K times and decrease values of MA and angle. CONCLUSIONS: Hemodilutions up to 40% increase coagulability and hemodilutions more than 70% decrease coagulability of whole blood in vitro.
