Trends of Mortality and Cause of Death among HIV-Infected Patients in Korea, 1990-2011.
10.3346/jkms.2013.28.1.67
- Author:
Sun Hee LEE
1
;
Kye Hyung KIM
;
Seung Geun LEE
;
Dong Hwan CHEN
;
Dong Sik JUNG
;
Chi Sook MOON
;
Ji Young PARK
;
Joo Seop CHUNG
;
Ihm Soo KWAK
;
Goon Jae CHO
Author Information
1. Deparment of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. mdssampak@yahoo.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
HIV;
Antiretroviral Therapy;
Mortality;
Cause of Death
- MeSH:
Acquired Immunodeficiency Syndrome/mortality;
Adult;
*Antiretroviral Therapy, Highly Active;
Cause of Death/*trends;
Female;
HIV Infections/drug therapy/*mortality;
Humans;
Kaplan-Meier Estimate;
Male;
Middle Aged;
Pneumonia, Pneumocystis/mortality;
Republic of Korea;
Retrospective Studies
- From:Journal of Korean Medical Science
2013;28(1):67-73
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although a decrease in acquired immunodeficiency syndrome (AIDS)-related mortality has been documented in highly active antiretroviral therapy (HAART) era, there are no published data comparing specific causes of death between pre-HAART and HAART era in Korea. Mortality and cause of death were analyzed in three treatment periods; pre-HAART (1990-1997), early-HAART (1998-2001), and late-HAART period (2002-2011). The patients were retrospectively classified according to the treatment period in which they were recruited. Although mortality rate per 100 person-year declined from 8.7 in pre-HAART to 4.9 in late-HAART period, the proportion of deaths within 3 months of initial visit to study hospital significantly increased from 15.9% in pre-HAART to 55.1% in late-HAART period (P < 0.001). Overall, 59% of deaths were attributable to AIDS-related conditions, and Pneumocystis pneumonia (PCP) was the most common cause of death (20.3%). The proportion of PCP as cause of death significantly increased from 8.7% in pre-HAART to 31.8% in late-HAART period (P < 0.001). Despite of significant improvement of survival, there was still a high risk of early death in patients presenting in HAART era, mainly due to late human immunodeficiency virus (HIV) diagnosis and late presentation to care.
