Prognostic Usefulness of Eosinopenia in the Pediatric Intensive Care Unit.
10.3346/jkms.2013.28.1.114
- Author:
Yoon Hee KIM
1
;
Hyun Bin PARK
;
Min Jung KIM
;
Hwan Soo KIM
;
Hee Seon LEE
;
Yoon Ki HAN
;
Kyung Won KIM
;
Myung Hyun SOHN
;
Kyu Earn KIM
Author Information
1. Department of Pediatrics and Institute of Allergy, Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. kwkim@yuhs.ac
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Biomarkers;
Child;
Eosinophils;
Infection;
Intensive Care Units;
Prognosis
- MeSH:
Agranulocytosis/*diagnosis;
Area Under Curve;
Biological Markers/blood;
Child;
Child, Preschool;
Eosinophils/*cytology;
Female;
*Hospital Mortality;
Humans;
Infant;
Infection/mortality/pathology;
*Intensive Care Units, Pediatric;
Leukocyte Count;
Male;
Predictive Value of Tests;
Prognosis;
ROC Curve;
Survival Rate
- From:Journal of Korean Medical Science
2013;28(1):114-119
- CountryRepublic of Korea
- Language:English
-
Abstract:
Eosinopenia, a biomarker for infection, has recently been shown to be a predictor of adult mortality in the intensive care unit (ICU). Our study assessed the usefulness of eosinopenia as a mortality and an infection biomarker in the pediatric ICU (PICU). We compared the PICU mortality scores, eosinophil count and percentage at ICU admission between children who survived and those who did not survive and between children with infection and those without infection. A total of 150 patients were evaluated. The initial eosinophil count and percentage were significantly lower in the group that did not survive when compared to those that did survive (P < 0.001; P < 0.001). However, there was no significant difference in the eosinophil count and percentage seen in patients with and without infection. Eosinopenia, defined as an eosinophil count < 15 cells/microL and an eosinophil percentage < 0.25%, (hazard ratio [HR]: 2.96; P = 0.008) along with a Pediatric Index of Mortality (PIM) 2 (HR: 1.03; P = 0.004) were both determined to be independent predictors of mortality in the PICU. The presence of eosinopenia at the ICU admission can be a useful biomarker for mortality in children, but is not useful as a biomarker for infection.
