The Effect on Liver Transaminases of 5-Methoxypsoralen Used in Systemic Photochemotherapy.
10.5021/ad.1995.7.1.51
- Author:
Hyun Joo CHOI
;
Soomin KIM
;
Seung Kyung HANN
;
Yoon Kee PARK
- Publication Type:Original Article
- Keywords:
Hepatotoxicity;
5-Methoxypsoralen;
Photochemotherapy
- MeSH:
Ficusin;
Furocoumarins;
Humans;
Liver Function Tests;
Liver*;
Photochemotherapy*;
Psoriasis;
PUVA Therapy;
Transaminases*;
Vitiligo
- From:Annals of Dermatology
1995;7(1):51-53
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: PUVA therapy has been used to treat psoriasis, vitiligo, and various cutaneous diseases. Psoralens are metabolized in the liver and thus can produce liver damage. OBJECTIVE: This study was done to observe the effect of 5-methoxypsoralen on liver function during photochemotherapy. METHODS: Serum transaminase levels were determined before and during photochemotherapy in eighty patients with vitiligo or psoriasis. RESULTS: Four of the eighty patients who had received 5-MOP-PUVA showed elevation of serum transaminase levels. CONCLUSION: Although there have been few cases showing transient elevated values of serum transaminase during 5-MOP-PUVA, it is advisable to obtain liver function tests before and serially during photochemotherapy.
