Treatment of Uncomplicated Male Gonococcal Urethritis with Clavulanate: Potentiated Amoxycillin.
- Author:
Joong Hwan KIM
;
Sung Ho KIM
;
Hoon HUR
;
Young Tae KIM
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Gonorrhoea;
Clavulanic acid;
Amoxycillin
- MeSH:
Amoxicillin*;
Clavulanic Acid*;
Humans;
Korea;
Male*;
Neisseria;
Penicillinase;
Probenecid;
Public Health;
Seoul;
Sexually Transmitted Diseases;
Urethritis*
- From:Korean Journal of Dermatology
1987;25(3):343-350
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
At the Venereal Disease Clinic of Choong-ku Public Health Center in Seoul ]03 male patients with uncomplicated gonococcal urethritis were allocated randomly into one of 2 treatment regimens and 101 patients were followed. All 51 patients, including PPNG infections, treated with clavulanate-potentiated amoxycillin, 375 mg, PO, t.i.d. for 5 days recovered(100%), Two(4%) of 50 patients treated with clavulanate-potentiated amoxycillin, 3. 25g, PO plus probenecid, lg, PO failed to recover. These cases were 2 of 25 Penicillinase Froducing Neisseria gonorrhoeae(PPNG) infections(failure rate of 8%) and all 25 non-PPNG infections recovered(100%). It is suggested that both of these clavulanate-potentiated amoxycillin regimens ha.ve similarly good effect with minimal side effects in the treatment of gonococcal urethritis and, because of high rate of PPNGs among circulating N, gonorrhoeae, they can be recommended as the first line treatment for gonorrhoa ir Korea.
