Hemodynamic Responses of Pretreatments Designed to Reduce Withdrawal Movements Following Rocuronium Injection: A Comparison of Alfentanil with Lidocaine.
10.4097/kjae.2008.54.5.507
- Author:
Sun Eun PARK
1
;
Se Hun PARK
;
Young Woo CHO
;
Hee Won SON
;
Ji Ho LEE
;
Dae Young KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, Korea. ywcho67@ulsan.ac.kr
- Publication Type:Original Article
- Keywords:
alfentanil;
hemodynamic change;
lidocaine;
rocuronium;
withdrawal movement
- MeSH:
Alfentanil;
Androstanols;
Anesthesia;
Blood Pressure;
Elbow;
Heart Rate;
Hemodynamics;
Humans;
Incidence;
Intubation;
Lidocaine;
Shoulder;
Thiopental;
Wrist
- From:Korean Journal of Anesthesiology
2008;54(5):507-512
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was conducted to compare the efficacy of intravenous alfentanil and lidocaine as a pretreatment for the prevention of withdrawal movements following a rocuronium injection and hemodynamic change following tracheal intubation. METHODS: This study evaluated 180 patients that were divided into the following 3 pretreatment groups: group C: normal saline, group L: lidocaine 1 mg/kg, group A: alfentanil 10microgram/kg. Anesthesia was induced using 5 mg/kg thiopental sodium, after which the test drug was injected. Rocuronium (1 mg/kg) was then administered 1 minute after the test drug was injected over 5 seconds and the response was characterized as one of the following: no movement, movement limited to the wrist, to the elbow or to the shoulder. Intubation was performed 1 minute later. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were then recorded at each of the following points: T1: preinduction, T2: immediately prior to rocuronium injection, T3: immediately after rocuronium injection, T4: immediately prior to intubation, T5: immediately after intubation, T6: 1 minute after intubation, T7: 5 minutes after intubation. RESULTS: The incidence of withdrawal movement was significantly lower in group A than groups C and L (P < 0.05). In addition, SBP, DBP and HR following intubation were significantly lower in group A than group C and group L (P < 0.05). CONCLUSIONS: Pretreatment with 10microgram/kg of alfentanil effectively reduced the incidence of withdrawal movement in response of rocuronium injection and caused minimal hemodynamic changes following intubation.
