MUC2 Expression Is Correlated with Tumor Differentiation and Inhibits Tumor Invasion in Gastric Carcinomas: A Systematic Review and Meta-analysis.
- Author:
Jung Soo PYO
1
;
Jin Hee SOHN
;
Guhyun KANG
;
Dong Hoon KIM
;
Kyungeun KIM
;
In Gu DO
;
Dong Hyun KIM
Author Information
- Publication Type:Meta-Analysis ; Original Article
- Keywords: Gastric carcinoma; MUC2; Clinicopathological significance; Meta-analysis
- MeSH: Classification; Humans; Lymph Nodes; Metaplasia; Neoplasm Metastasis
- From:Journal of Pathology and Translational Medicine 2015;49(3):249-256
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: While MUC2 is expressed in intestinal metaplasia and malignant lesions, the clinicopathological significance of MUC2 expression is not fully elucidated in gastric carcinoma (GC). METHODS: The present study investigated the correlation between MUC2 expression and clinicopathological parameters in 167 human GCs. In addition, to confirm the clinicopathological significance of MUC2 expression, we performed a systematic review and meta-analysis in 1,832 GCs. RESULTS: MUC2 expression was found in 58 of 167 GCs (34.7%). MUC2-expressing GC showed lower primary tumor (T), regional lymph node (N), and tumor node metastasis (TNM) stages compared with GCs without MUC2 expression (p=.001, p=.001, and p=.011, respectively). However, MUC2 expression was not correlated with Lauren's classification and tumor differentiation. In meta-analysis, MUC2 expression was significantly correlated with differentiation and lower tumor stage (odds ratio [OR], 1.303; 95% confidence interval [CI], 1.020 to 1.664; p = .034 and OR, 1.352; 95% CI, 1.055 to 1.734; p = .017, respectively) but not with Lauren's classification, pN stage, or pTNM stage. CONCLUSIONS: MUC2 expression was correlated with a lower tumor depth and lower lymph node metastasis in our study; the meta-analysis showed a correlation of MUC2 expression with tumor differentiation and lower tumor depth.
