Atypical Glandular Cells of Undetermind Significances (AGUS) ; Histopathologic Results and the Significance of the HPV DNA Detection.
- Author:
Chan Joo KIM
;
Tae Chul PARK
;
Jong Sup PARK
;
Jun Mo LEE
;
Seung Jo KIM
;
Sung Eun NAMKOONG
- Publication Type:Original Article
- Keywords:
AGUS (Atypical Glandular Cells of Undetermined Significance);
HPV (Human papilloma virus);
Cervical Cancer
- MeSH:
Adenocarcinoma;
Carcinoma, Squamous Cell;
Colposcopy;
Diagnosis;
DNA*;
Endometrial Hyperplasia;
Endometrial Neoplasms;
Endometriosis;
Female;
Human Papillomavirus DNA Tests;
Humans;
Middle Aged;
Papanicolaou Test;
Triage;
Uterine Cervical Neoplasms
- From:Korean Journal of Obstetrics and Gynecology
2000;43(7):1154-1161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: AGUS often reflects an immediate cervical cancer precursor such as a HSIL mimicking an endocervical glandular lesion. In this study, we attempted to assess the clinical significance of a cytologic diagnosis of atypical glandular cells of undetermined significance (AGUS) and determine the usefulness of the human papillomavirus (HPV) DNA testing as the triage strategies in evaluating AGUS. METHODS: Between 1994 and 1998, 67,730 Papanicolaou smears were evaluated at Kangnam and Uijongbu St Mary's Hospital. There were 87 (0.13%) cases of AGUS smears during that time. Colposcopy was performed on all women, and HPV DNA testing was performed on 11 persons. RESULTS: Mean age of these patients was 45.8 years. Histologic diagnosis of AGUS were kolocytosis and CIN-I in 6 (6.9%), CIS in one, endometrial hyperplasia in 2 (2.3%), endometrial adenocarcinoma in 7 (8.0%), cervical adenocarcinoma in 14 (16.1%) and cervical squamous cell carcinoma in 2 (2.3%) cases. Endometriosis was 8.9% under 46 years old and none in over 46. CIN was 8.9% and 7.2%, respectively. Cervical adenocarcinoma was 6.7% under 46 and 19.1% over 46. Endometrial cancer was 4.4% and 11.9%, respectively. The risk of cervical cancer and endometrial cancer was high in the AGUS with
