A Korean patient with Guillain-Barré syndrome following acute hepatitis E whose cholestasis resolved with steroid therapy.
- Author:
Sung Bok JI
1
;
Sang Soo LEE
;
Hee Cheul JUNG
;
Hong Jun KIM
;
Hyun Jin KIM
;
Tae Hyo KIM
;
Woon Tae JUNG
;
Ok Jae LEE
;
Dae Hyun SONG
Author Information
- Publication Type:Case Reports
- Keywords: Hepatitis E; Jaundice; Steroid treatment; Guillain-Barré syndrome
- MeSH: Acute Disease; Alanine Transaminase/blood; Antibodies, Viral/blood; Aspartate Aminotransferases/blood; Bilirubin/analysis; Cholestasis/*drug therapy; Guillain-Barre Syndrome/complications/*diagnosis; Hepatitis E/*diagnosis/etiology; Hepatitis E virus/immunology; Humans; Immunoglobulin M/blood; Liver/pathology; Male; Middle Aged; Prednisolone/therapeutic use; Republic of Korea; Steroids/*therapeutic use
- From:Clinical and Molecular Hepatology 2016;22(3):396-399
- CountryRepublic of Korea
- Language:English
- Abstract: Autochthonous hepatitis E virus (HEV) is an emerging pathogen in developed countries, and several cases of acute HEV infection have been reported in South Korea. However, there have been no reports on HEV-associated Guillain-Barré syndrome (GBS) in Korea. We recently experienced the case of a 58-year-old Korean male with acute HEV infection after ingesting raw deer meat. Persistent cholestasis was resolved by the administration of prednisolone. At 2.5 months after the clinical presentation of HEV infection, the patient developed weakness of the lower limbs, and was diagnosed with GBS associated with acute hepatitis E. To our knowledge, this is the second report on supportive steroid therapy for persistent cholestasis due to hepatitis E, and the first report of GBS in a Korean patient with acute HEV infection.
