Live birth in a woman with recurrent implantation failure and adenomyosis following transfer of refrozen-warmed embryos.
10.5653/cerm.2016.43.3.181
- Author:
Somayyeh SAFARI
1
;
Azita FARAMARZI
;
Azam AGHA-RAHIMI
;
Mohammad Ali KHALILI
Author Information
1. Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Azam_Agharahimi63@yahoo.com
- Publication Type:Case Report
- Keywords:
Adenomyosis;
Embryo;
Live birth;
Vitrification
- MeSH:
Adenomyosis*;
Adult;
Embryo Transfer;
Embryonic Structures*;
Female;
Fertilization in Vitro;
Humans;
Live Birth*;
Ovarian Hyperstimulation Syndrome;
Polycystic Ovary Syndrome;
Sperm Injections, Intracytoplasmic;
Uterus;
Vitrification
- From:Clinical and Experimental Reproductive Medicine
2016;43(3):181-184
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim was to report a healthy live birth using re-vitrified-warmed cleavage-stage embryos derived from supernumerary warmed embryos after frozen embryo transfer (ET) in a patient with recurrent implantation failure (RIF). The case was a 39-year-old female with a history of polycystic ovarian syndrome and adenomyosis, along with RIF. After ovarian hyperstimulation, 33 cumulus-oocyte complexes were retrieved and fertilized with conventional in vitro fertilization and intracytoplasmic sperm injection. Because of the risk of ovarian hyperstimulation syndrome, 16 grade B and C embryos were vitrified. After 3 and 6 months, 3 and 4 B–C warmed embryos were transferred to the uterus, respectively. However, implantation did not take place. Ten months later, four embryos were warmed, two grade B 8-cell embryos were transferred, and two embryos were re-vitrified. One year later, the two re-vitrified cleavage-stage embryos were warmed, which resulted in a successful live birth. This finding showed that following first warming, it is feasible to refreeze supernumerary warmed embryos for subsequent ET in patients with a history of RIF.
