Experimental Degeneration of the Rabbits Retina by Sodium Glutamate.
- Author:
Hae Sook LEE
1
Author Information
1. Department of Ophthalmology, School of Medicinc, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Adult;
Glutamic Acid;
Humans;
Injections, Intraperitoneal;
Intravitreal Injections;
Rabbits*;
Retina*;
Retinal Degeneration;
Retinaldehyde;
Sodium Glutamate*;
Sodium*
- From:Journal of the Korean Ophthalmological Society
1972;13(3):121-126
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Intravitreal and intraperitoneal administrations of sodium L-glutamate induced the retinal degenerations in adult rabbits. Electroretiongram was completely extinguished by the intravitreal injection of glutamate (50mg in 0.1ml) followed by slight recovery. The retina showed marked thinning with almost diffuse degeneration in all retinal layers. Intraperitoneal injection of a sigle large dose of glutamate(8g/Kg) produced moderate reduction in the amplitudes of a-and b-waves with degenerative changes in the retina, mainly involving the inner layers and the periphery of the fundus, parallel to the ERG changes. Administrations of small doses (2.5g/Kg and 5.0g/Kg) for 7 days induced moderate reduction in the a-and b-waves with slight histological changes, especially marked in the inner layers of the retina. Possible mechanisms of the toxic effects of glutamate were discussed.
