Lipoprotein(a) Levels Relate to Vascular Complications in Patients with Non-Insulin-Dependent Diabetes Mellitus(NIDDM).
- Author:
Seon Hee KIM
1
;
Hee Book CHAI
;
Joong Yeol PARK
;
Won Ki MIN
;
Woo Kun KIM
;
Ghi Su KIM
;
Ki Up LEE
Author Information
1. Department of Internal Medicine, University of Ulsan, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Lp(a);
NIDDM;
Coronary artery disease;
Diabetic retinopathy;
Diabetic nephropathy
- MeSH:
Coronary Artery Disease;
Coronary Vessels;
Diabetes Mellitus, Type 2;
Diabetic Angiopathies;
Diabetic Nephropathies;
Diabetic Retinopathy;
Enzyme-Linked Immunosorbent Assay;
Humans;
Light Coagulation;
Lipoprotein(a)*;
Logistic Models;
Proteinuria
- From:Korean Journal of Medicine
1997;52(3):334-341
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: High serum Lp(a) concentration is associated with a high risk of coronary artery disease(CAD). This study was initiated to determine whether increased Lp(a) levels are associated with diabetic vascular complications in Korean patients with NIDDM. METHODS: A total of 183 NDDM patients were studied cross-sectionally for the presence of various vascular complications. Lp(a) levels were measured by 1-step sandwich ELISA method. RESULTS: The patients with overt proteinuria had higher Lp(a) levels than the patients with mormoalbuminuria or microalbuminuria(26.8mg/dl vs 13.8 mg/dl and 17.3mg/dl, p<0.05), The patients with proliferative retinopathy and/or those treated by photocoagulation had higher Lp(a) levels than those without retinopathy or those with background retinopathy(34.1mg/dl vs 13.3mg/dl and 16,9mg/dl, p<0.05), The Lp(a) levels were also higher in the patients with CAD than those without CAD(30.9mg/ dl vs 16.3mg/dl, p<0.05). Multiple logistic regression analysis revealed that high Lp(a) levels were independantly associated with CAD and severe diabetic retinopath3. CONCLUSION: High Lp(a) levels are associated with CAD and proliferative retinopathy in Korean patients with NIDDM.
