Functional Mapping of the Neural Basis for the Encoding and Retrieval of Human Episodic Memory Using H215O PET.
- Author:
Jae Sung LEE
;
Hyun Woo NAM
;
Dong Soo LEE
;
Sang Kun LEE
;
Myoung Jin JANG
;
Ji Young AHN
;
Kwang Suk PARK
;
June Key CHUNG
;
Myung Chul LEE
- Publication Type:Original Article
- Keywords:
H215O PET;
Brain activation;
Statistical parametric mapping;
Episodic memory
- MeSH:
Brain;
Cerebellum;
Gyrus Cinguli;
Healthy Volunteers;
Humans*;
Memory;
Memory, Episodic*;
Positron-Emission Tomography;
Prefrontal Cortex
- From:Korean Journal of Nuclear Medicine
2000;34(1):10-21
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Episodic memory is described as an 'autobiographical' memory responsible for storing a record of the events in our lives. We performed functional brain activation study using H215O PET to reveal the neural basis of the encoding and the retrieval of episodic memory in human normal volunteers. MATERIALS AND METHODS: Four repeated H215O PET scans with two reference and two activation tasks were performed on 6 normal volunteers to activate brain areas engaged in encoding and retrieval with verbal materials. Images from the same subject were spatially registered and normalized using linear and nonlinear transformation. Using the means and variances for every condition which were adjusted with analysis of covariance, t-statistic analysis were performed voxel-wise. RESULTS: Encoding of episodic memory activated the opercular and triangular parts of left inferior frontal gyrus, right prefrontal cortex, medial frontal area, cingulate gyrus, posterior middle and inferior temporal gyri, and cerebellum, and both primary visual and visual association areas. Retrieval of episodic memory activated the triangular part of left inferior frontal gyrus and inferior temporal gyrus, right prefrontal cortex and medial temporal area, and both cerebellum and primary visual and visual association areas. The activations in the opercular part of left inferior frontal gyrus and the right prefrontal cortex meant the essential role of these areas in the encoding and retrieval of episodic memory. CONCLUSION: We could localize the neural basis of the encoding and retrieval of episodic memory using H215O PET, which was partly consistent with the hypothesis of hemispheric encoding/retrieval asymmetry.
