Expression of Matrix Metalloproteinase-2 and -13 and Tissue Inhibitor of Metalloproteinase-4 in Varicose Veins.
10.5090/kjtcs.2011.44.6.387
- Author:
Jee Won CHANG
1
;
Young Hee MAENG
;
Su Wan KIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Jeju National University Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Veins;
Varicose veins;
Extracellular matrix
- MeSH:
Aged;
Extracellular Matrix;
Female;
Humans;
Hypertension;
Ligation;
Male;
Matrix Metalloproteinase 2;
Matrix Metalloproteinases;
Ocimum basilicum;
Renal Dialysis;
Saphenous Vein;
Tissue Inhibitor of Metalloproteinases;
Varicose Veins;
Veins
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2011;44(6):387-391
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The relationship between the degree of expression of matrix metalloproteinases or tissue inhibitor of metalloproteinases and venous reflux remains to be investigated. MATERIALS AND METHODS: Primary varicose vein tissues were obtained from 23 patients, 18 females and 5 males, aged from 19 to 73. Cephalic or basilic veins were obtained for the control group from 10 patients who underwent vascular access for maintenance hemodialysis. Two operative techniques (high ligation with stripping or endovenous laser coagulation) were used. The expression of matrix metalloproteinase-2 and 13 and tissue inhibitor of metalloproteinase-4 in the varicose vein group and control group was assessed semi-quantitatively by immunohistochemical slides stained with primary antibodies. RESULTS: Twenty (87%) of the varicose vein group patients had greater or lesser saphenous vein diseases with reflux. The focal weak (+) stain for matrix metalloproteinases-2, and 13, and tissue inhibitor of matrix metalloproteinase-4 was dominant in the varicose vein group; the focal or diffuse strong stain (++ or +++) was prevalent in the control group. The differences were statistically significant (p<0.01). The degree of reflux and the duration of symptoms were not significantly related to the expression of MMP-13 (p=0.317 and p=0.654, respectively). CONCLUSION: Further study should be performed to investigate the relationship between the clinical characteristics related to venous hypertension or reflux and expression of MMPs and TIMP in varicose veins.
