The Clinical Usefulness of Cystatin C in Evaluating Renal Function in Children with Various Renal Diseases.
- Author:
Khi Joo KIM
1
;
Joung A KIM
;
Jae Il SHIN
;
You Sik HWANG
;
Il Chun CHEUNG
;
Jae Seung LEE
;
Jong Baeck LIM
Author Information
1. Department of Pediatrics, Severance Children Hospital, The Institute of Kidney Disease, Korea. jsyonse@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Glomerular filtration rate;
Cystatin C;
Creatinine;
Creatinine Clearance
- MeSH:
Child*;
Creatinine;
Cystatin C*;
Filtration;
Glomerular Filtration Rate;
Humans;
Retrospective Studies
- From:Journal of the Korean Society of Pediatric Nephrology
2007;11(2):161-167
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: GFR(glomerular filtration rate) is a fundamental parameter in detecting renal impairment and predicts the progression of renal disease. Because serum creatinine has several disadvantages, serum cystatin C has been recently proposed as a new endogenous marker for GFR. We compared serum cystatin C with creatinine and creatinine clearance to investigate the clinical usefulness of cystatin C. METHODS: We retrospectively analyzed 46 patients(60 case numbers) who had various renal diseases and classified them into 3 groups according to creatinine clearance(Group 1 : CrCl <40 mL/min/1.73m2, Group 2 : CrCl 40-60 mL/min/1.73m2, Group 3 : CrCl >60 mL/min/1.73 m2). We measured serum creatinine, cystatin C and creatinine clearance and also analyzed the correlations among them. RESULTS: Serum cystatin C and creatinine showed a similar correlation to creatinine clearance (r=0.685, r=0.640, respectively) and showed similar diagnostic accuracy in detecting decreased GFR(AUC, cystatin C 0.829 vs. creatinine 0.826, P=0.848). Serum cystatin C showed a greater sensitivity for detecting a decreased GFR than creatinine in Group 2 and 3(Group 1 : 100% vs. 100%, Group 2 : 70% vs. 35%, Group 3 : 46% vs. 15%). CONCLUSIONS: Serum cystatin C could be a useful endogenous marker for GFR and would be superior to serum creatinine in early detection of renal impairment in pediatric patients with renal diseases.
