A Case of Disulfiram Neuropathy.
- Author:
Do Kwon HONG
1
;
Hyeong Jun KIM
;
Jong Su YE
;
Oeung Kyo KIM
;
Kyoung HEO
;
Hyo Kun CHO
Author Information
1. Department of Neurology, College of Medicine, Inje University, Korea.
- Publication Type:Original Article
- MeSH:
Adult;
Alcoholism;
Apathy;
Biopsy;
Disulfiram*;
Eating;
Headache;
Humans;
Nervous System Diseases;
Optic Neuritis;
Polyneuropathies;
Sleep Stages
- From:Journal of the Korean Neurological Association
1995;13(3):682-688
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Disulfiram, tetraethylthiuram disulfide, has been used in the clinical treatment of alcoholism since 1948. Aside from the manifestations of a disulfiram-alcohol reaction, disulfiram causes direct toxic side effects including psychiatric, cardiovascular, hematologic and neurologic disorders. The most frequent neurologic side effects are drowsiness, apathy, headache, decreased sexual potency, neuropathy, and optic neuritis. We describe a 26-year-old man who insidiously developed a distal synunetric sensorimotor polyneuropathy after seven years of disulfiram ingestion confirmed by nerve biopsy. He showed nearly complete resolution after the disulfiram was stopped.
