Melatonin does not attenuate dynamic cardiovascular and cerebrovascular reflex responses to acute hypotension in healthy men.
10.4097/kjae.2012.63.3.245
- Author:
Jiyoun BANG
1
;
Yong Seok PARK
;
Sung Moon JEONG
;
Jun Gol SONG
;
Young Kug KIM
;
Gyu Sam HWANG
Author Information
1. Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kshwang@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Blood pressure;
Cerebrovascular circulation;
Melatonin
- MeSH:
Arterial Pressure;
Blood Flow Velocity;
Blood Pressure;
Cardiac Output;
Cerebrovascular Circulation;
Eating;
Heart Rate;
Hemorrhage;
Homeostasis;
Humans;
Hypotension;
Male;
Melatonin;
Premedication;
Reflex;
Thigh;
Vascular Resistance
- From:Korean Journal of Anesthesiology
2012;63(3):245-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Melatonin has been shown to attenuate the reflex sympathetic increases that arise in response to orthostatic challenges. We tested the hypothesis that the attenuated sympathetic increase induced by melatonin premedication may weaken the arterial blood pressure (ABP) preserving the capability during acute hypotension, thereby altering dynamic cerebral autoregulation and causing a further decrease in cerebral blood flow (CBF). METHODS: Acute hypotension was induced in 12 healthy subjects by releasing bilateral thigh cuffs before and after an oral dose of melatonin (0.2 mg/kg). Heart rate (HR), arterial blood pressure (ABP), Modelflow estimate of cardiac output (CO), total peripheral resistance (TPR) and cerebral blood flow velocity (CBFV) by transcranial Doppler were measured. RESULTS: Steady state HR, the mean arterial pressure and CBFV were not altered 60 minutes after melatonin ingestion. Reduced systolic arterial pressure (DeltaSAP), changes in HR (DeltaHR), CO (DeltaCO), and TPR (DeltaTPR), DeltaHR/DeltaSAP and percentage restoration of SAP were not affected after a temporal decrease in ABP induced by thigh cuff release. In the cerebral circulation, melatonin did not affect changes in CBFV, cerebrovascular resistance index, the rate of regulation and percentage restoration of CBFV following a sudden decrease in ABP. CONCLUSIONS: Contrary to our hypothesis, melatonin did not affect the rapid vasodilatory and recovery responses of cardiovascular and dynamic cerebral autoregulation. These results suggest that melatonin premedication may not impair ABP and CBF preserving capability induced by sudden postural changes or hemorrhage.
