Immobilization-Induced Hypercalcemic Nephropathy Associated with Acute Kidney Injury.
- Author:
Hyun Ju OH
1
;
Ji Soo PARK
;
Jo Eun KIM
;
Harry YOON
;
Ji Soo KIM
;
Heo Young KIM
;
Hyung Jong KIM
Author Information
1. Department of Internal Medicine, Bundang CHA Medical Center, CHA University, Seongnam, Korea. khj04@cha.ac.kr
- Publication Type:Case Report
- Keywords:
Hypercalcemia;
Acute kidney injury;
Immobilization;
Glucocorticoids
- MeSH:
Acute Kidney Injury;
Bone Resorption;
Breast Neoplasms;
Glucocorticoids;
Humans;
Hypercalcemia;
Hypercalciuria;
Hyperparathyroidism, Primary;
Immobilization;
Lung;
Middle Aged;
Multiple Myeloma;
Osteoblasts;
Osteoclasts;
Osteogenesis
- From:Korean Journal of Medicine
2012;82(6):744-748
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hypercalcemia commonly occurs because of primary hyperparathyroidism and metastatic malignancies, such as multiple myeloma, breast cancer and lung cancer; these causes account for 90% of cases. The other causes of hypercalcemia are numerous, and immobilization is an under-appreciated etiology. The mechanisms underlying immobilization-induced hypercalcemia are uncertain. However, an overall increased osteoclastic bone resorption and decreased osteoblastic bone formation can induce hypercalciuria and hypercalcemia. Additionally, hypercalcemia can induce and be associated with acute kidney injury, but it is rarely reported in immobilization hypercalcemia. We report here a 58-year-old man with suspected immobilization hypercalcemia associated with acute kidney injury and treated successfully with glucocorticoids.
