Cerebral Infarction in Essential Thrombocythemia after Discontinuation of Hydroxyurea.
- Author:
Jung Mee KIM
;
Eun Kyoung CHO
;
Young Soo HAN
;
Jeong Ho HAN
;
Doo Eung KIM
- Publication Type:Original Article
- Keywords:
Hydroxyurea;
Essential thrombocythemia;
Cerebral infarctio
- MeSH:
Aged;
Cerebral Infarction*;
Dysarthria;
Headache;
Heparin;
Humans;
Hydroxyurea*;
Infarction;
Paresis;
Platelet Count;
Thrombocythemia, Essential*
- From:Journal of the Korean Geriatrics Society
2003;7(2):159-163
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Abnormalities in the number and function of platelets may contribute to thromboembolic complications in patients with essential thrombocythemia(ET). Physicians often use hydroxyurea which reduces the platelet count for the initial treatment of ET. A 74-year-old man with ET was presented with headache, dysarthria, and right hemiparesis 10 months after discontinuation of hydroxyurea. Initial platelet count was 450x103/microliter and we gave him heparin. However, his platelet count rised upto 1,019x103/microliter within 4 days. He was on hydroxyurea 1.5 g/day and his symptoms improved with decrease of platelet count. We report a case of left MCA(middle cerebral artery) multifocal infarction in ET after discontinuation of hydroxyurea.
