The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects.
10.4093/dmj.2011.35.2.138
- Author:
Eun Jung RHEE
1
;
Ji Hun CHOI
;
Seung Hyun YOO
;
Ji Cheol BAE
;
Won Jun KIM
;
Eun Suk CHOI
;
Se Eun PARK
;
Cheol Young PARK
;
Seok Won PARK
;
Ki Won OH
;
Sung Woo PARK
;
Sun Woo KIM
;
Won Young LEE
Author Information
1. Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. drlwy@hanmail.net
- Publication Type:Original Article
- Keywords:
Glycemic progression;
Prediabetes;
Skeletal muscle index;
Visceral obesity;
Weight change
- MeSH:
Body Composition;
Body Weight;
Cohort Studies;
Electric Impedance;
Fasting;
Follow-Up Studies;
Glucose;
Homeostasis;
Logistic Models;
Longitudinal Studies;
Metabolome;
Muscle, Skeletal;
Obesity, Abdominal;
Odds Ratio;
Prediabetic State;
Retrospective Studies;
Waist-Hip Ratio;
Weight Gain;
Weight Loss
- From:Diabetes & Metabolism Journal
2011;35(2):138-148
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA) indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional intervention. METHODS: From 28,440 non-diabetic subjects who participated in a medical check-up program in 2004, data on anthropometric and metabolic parameters were obtained after four years in 2008. Body composition analyses were performed with a bioelectrical impedance analyzer. Skeletal muscle index (SMI, %) was calculated with lean mass/weightx100. Subjects were divided into three groups according to weight change status in four years: weight loss (< or =-5.0%), stable weight (-5.0 to 5.0%), weight gain (> or =5.0%). Progressors were defined as the subjects who progressed to impaired fasting glucose or diabetes. RESULTS: Progressors showed worse baseline metabolic profiles compared with non-progressors. In logistic regression analyses, the increase in changes of HOMA-insulin resistance (HOMA-IR) in four years presented higher odds ratios for glycemic progression compared with other changes during that period. Among the components of body composition, a change in waist-hip ratio was the strongest predictor, and SMI change in four years was a significant negative predictor for glycemic progression. Changes in HOMA beta-cell function in four years was a negative predictor for glycemic progression. CONCLUSION: Increased interval changes in HOMA-IR, weight gain and waist-hip ratio was associated with glycemic progression during a four-year period without intentional intervention in non-diabetic Korean subjects.
