Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea.
- Author:
Kyu Young CHOI
1
;
Dong Young KIM
Author Information
- Publication Type:Original Article
- Keywords: Pyroglyphidae; Dermatophagoides pteronyssinus; Antigens, Dermatophagoides; Rhinitis, allergic; Sublingual immunotherapy
- MeSH: Allergens; Antibodies; Antigens, Dermatophagoides; Dermatophagoides pteronyssinus; Humans; Hypersensitivity; Immunoglobulin E*; Immunotherapy; Korea*; Prevalence; Pyroglyphidae; Rhinitis, Allergic*; Sublingual Immunotherapy
- From:Journal of Rhinology 2016;23(2):91-96
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND AND OBJECTIVES: To evaluate IgE reactivity profiles to Der p 1, Der p 2, and Der p 10 in house dust mite (HDM) allergic rhinitis (AR) patients in Korea. Symptomatic and serologic changes after sublingual immunotherapy (SLIT) were analyzed according to IgE profiles. MATERIALS AND METHODS: Sixty AR patients diagnosed with an HDM allergy were tested for the presence of IgE antibodies against purified HDM allergen molecules (i.e., nDer p 1, rDer p 2, and rDer p 10) and native Dermatophagoides pteronyssinus (Dp) using ImmunoCAP 250®. Symptom scores and laboratory findings were analyzed after SLIT. RESULTS: Prevalence rates of IgE for Dp, Der p 1, Der p 2, and Der p 10 were 100%, 98.3%, 93.3%, and 8.3%, respectively. After one year of immunotherapy with SLITone○R (standardized to major allergens, but not Der p 10), symptom scores and laboratory findings improved in patients with and without Der p 10 IgE antibodies. CONCLUSION: In Korean AR patients, specific IgE antibodies to Der p 1 or Der p 2 are present in most Dp-allergic patients, while reactivity to Der p 10 is very low. Allergic symptoms improved in patients with Der p 10 IgE antibodies after SLIT.
