The Effect of Breastfeeding Duration and Parity on the Risk of Epithelial Ovarian Cancer: A Systematic Review and Meta-analysis.
- Author:
Ho Kyung SUNG
1
;
Seung Hyun MA
;
Ji Yeob CHOI
;
Yunji HWANG
;
Choonghyun AHN
;
Byoung Gie KIM
;
Yong Man KIM
;
Jae Weon KIM
;
Sokbom KANG
;
Jaehoon KIM
;
Tae Jin KIM
;
Keun Young YOO
;
Daehee KANG
;
Suekyung PARK
Author Information
- Publication Type:Meta-Analysis ; Review
- Keywords: Ovarian neoplasms; Parity; Breast feeding; Reproduction; Risk factors; Meta-analysis
- MeSH: Birth Order; Breast Feeding*; Female; Humans; Joints; Ovarian Neoplasms*; Parity*; Parturition; Population Characteristics; Reproduction; Risk Factors
- From:Journal of Preventive Medicine and Public Health 2016;49(6):349-366
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVES: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). METHODS: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I²=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I²=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. CONCLUSIONS: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk.
