c-Myc expression is related with cell proliferation and associated with poor clinical outcome in human gastric cancer.
10.3346/jkms.1999.14.5.526
- Author:
Sehwan HAN
1
;
Hong Yong KIM
;
Kyeongmee PARK
;
Hye Jae CHO
;
Myung Soo LEE
;
Hong Joo KIM
;
Young Duck KIM
Author Information
1. Department of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea. shwhan@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Cell division;
Stomach neoplasms;
Immunohistochemistry;
Proto-oncogene proteins, myc;
Prognosis;
Survival
- MeSH:
Adult;
Aged;
Cell Division;
Female;
Flow Cytometry;
Human;
Immunohistochemistry;
Lymphatic Metastasis;
Male;
Middle Age;
Neoplasm Invasiveness;
Neoplasm Staging;
Proto-Oncogene Proteins c-myc/analysis*;
Stomach/pathology;
Stomach/chemistry;
Stomach Neoplasms/pathology;
Stomach Neoplasms/mortality;
Stomach Neoplasms/chemistry*;
Survival Rate
- From:Journal of Korean Medical Science
1999;14(5):526-530
- CountryRepublic of Korea
- Language:English
-
Abstract:
We underwent protein assay for Myc expression in 76 human gastric cancer tissues using immunohistochemistry. Expression of Myc protein was analyzed according to proliferative indices measured by flow cytometry. Levels of Myc protein expression was evaluated by correlating with biologic and clinical parameters. In 36 (47.4%) of 76 primary gastric cancers, overexpression of Myc was observed. We could observe expression of Myc protein in a significant portion of early gastric cancer (42.9%). Expression of Myc protein was demonstrated to be more frequent in poorly differentiated cancer cells (p=0.043). However, expression of Myc protein had little influence over progress or extent of the disease. Expression of Myc protein was significantly correlated with increased proliferative activity (p=0.032) and patients with high levels of Myc expression had poor disease-free survival. In a certain proportion of human gastric cancer, Myc protein may function as a regulator of cancer cell growth and expression of Myc may represent an aggressive phenotype of gastric cancer.
