A Case of Atypical McCune-Albright Syndrome Associated with Hyperthyroidism and Hypersecretion of Growth Hormone.
- Author:
Moon Bin YOU
1
;
Ki Hoon KANG
;
Byung Soo LEE
;
Eun Ha CHAE
;
Myung Chan KIM
;
Jae Il JUNG
;
Sun Hee PARK
;
Hyo Jin LEE
;
Seok Tae JUNG
Author Information
1. Department of internal medicine, Seoul Adventist Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
McCune-Albright syndrome;
Fibrous dysplasia;
Hyperthyroidism;
Growth hormone hypersecretion
- MeSH:
Adolescent;
Adult;
Autoantibodies;
Bromocriptine;
Female;
Fibrous Dysplasia, Polyostotic*;
Glucose;
Goiter;
Growth Hormone*;
Humans;
Hyperthyroidism*;
Magnetic Resonance Imaging;
Pigmentation;
Pituitary Gland;
Protein Subunits;
Puberty;
Puberty, Precocious;
Skin;
Thyroid Gland;
Whole Body Imaging
- From:Journal of Korean Society of Endocrinology
2003;18(4):426-432
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
McCune-Albright syndrome is characterized by polyostotic fibrous dysplasia, Caf -au-lait pigmentation and precocious puberty or other endocrinopathy. It can be caused by substitution of His, Cys or Gly for Arg 201st amino acid of the Gs protein subunit. The case of a 32-year-old woman, with atypical McCune-Albright syndrome, is reported. She had no skin lesion or precocity puberty. The polyostotic fibrous dysplasia was examined by a simple radiological image and whole body scan. She developed hyperthyroidism, with a multinodular toxic goiter. No thyroid related autoantibodies were detected. The cause of hyperthyroidism was thought to be a non- autoimmune thyroid hyperfunction. The level of growth hormone was not suppressed by oral glucose load. After a bromocriptine suppression test, the level of growth hormone decreased. There was no mass in the pituitary gland on a sellar MRI. A case of atypical McCune-Albright syndrome, including hyperthyroidism and hypersecretion of growth hormone, is reported.
