A Case of Anaphylaxis to Oral Minocycline.
10.3346/jkms.2010.25.8.1231
- Author:
Ji Woong JANG
1
;
Yun Jeong BAE
;
Yong Giun KIM
;
Young Joo JIN
;
Kyung Sun PARK
;
You Sook CHO
;
Hee Bom MOON
;
Tae Bum KIM
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Anaphylaxis;
Minocycline;
Oral Challenge Test;
Allergy
- MeSH:
Administration, Oral;
Anaphylaxis/chemically induced/*diagnosis;
Anti-Bacterial Agents/*adverse effects;
Drug Hypersensitivity/diagnosis;
Female;
Humans;
Middle Aged;
Minocycline/*adverse effects;
Recurrence
- From:Journal of Korean Medical Science
2010;25(8):1231-1233
- CountryRepublic of Korea
- Language:English
-
Abstract:
Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. To date, there has been only one case report of anaphylaxis to minocycline. We report here a case of anaphylaxis to oral minocycline. A 56-yr-old woman visited our hospital after three episodes of recurrent anaphylaxis. We performed an oral challenge test, the standard method for diagnosing drug allergies, with minocycline, one of the drugs she had taken previously. She developed urticaria, angioedema, nausea, vomiting, hypotension, and dyspnea within 4 min and was treated with intramuscular epinephrine, intravenous antihistamine and systemic corticosteroid. However, she presented similar symptoms at 50 min and at 110 min. In prescribing oral minocycline, physicians should consider the possibility of serious adverse reactions, such as anaphylaxis.
