Relationship between End-Tidal CO2 and Frequency of Interictal Spikes during Hyperventilation in Temporal Lobe Epilepsy.
- Author:
Seonhye KIM
1
;
Oh Young KWON
;
Heeyoung KANG
;
Ki Jong PARK
;
Nack Cheon CHOI
;
Byeong Hoon LIM
Author Information
1. Department of Neurology, Gyeongsang National University College of Medicine, Jinju, Korea. oykwon@nongae.gsnu.ac.kr
- Publication Type:Original Article
- Keywords:
Hyperventilation;
Temporal lobe epilepsy;
Carbon dioxide
- MeSH:
Carbon Dioxide;
Electroencephalography;
Epilepsy, Temporal Lobe*;
Humans;
Hyperventilation*;
Seizures;
Temporal Lobe*
- From:Journal of Korean Epilepsy Society
2006;10(1):41-45
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine whether the change of end-tidal pCO2 (ETCO2) level by hyperventilation evokes seizures or epileptiform discharges in temporal lobe epilepsy. METHODS: Twenty-four temporal lobe epilepsy patients were enrolled in this study. Hyperventilation was done for 5 min during EEG recording. We gathered data on ETCO2 levels during hyperventilation. The data included baseline ETCO2 (B-ETCO2), ETCO2 after 5 min of hyperventilation (5 min-ETCO2), the mean value of the ETCO2 (M-ETCO2), and the change in ETCO2 between baseline and the level after 5 min of hyperventilation (delta ETCO2). We counted the numbers of interictal spikes and considered the cases with more than 120% increments of the number during hyperventilation as the cases with the increased number of spikes. We compared the four variables between two groups, divided according to the increment to hyperventilation. RESULTS: Seizures were not induced by hyperventilation in all the cases. Thirteen of 24 patients were in the increment group. The M-ETCO2 was 33.0+3.3 mmHg (mean+SD) in the increment group and 29.4+5.3 in the no-increment group (p=0.064). The delta ETCO2 was 13.0+5.3 and 14.0+5.3, respectively (p=0.622). The 5 min-ETCO2 was 28.2+4.8 and 24.8+5.9, respectively (p=0.077). CONCLUSION: In this study, the frequency of interictal spikes was increased well by hyperventilation. The spike increments were not associated with the ETCO2 level or the change of that, but maybe with the individual susceptibility.
