Pancreatic Neuroendocrine Tumor Presenting with Arthritis and Panniculitis.
10.4078/jrd.2017.24.5.313
- Author:
Hyung Rae KIM
1
;
Jae Sung AHN
;
Jin Hee NOH
;
Hee Jeong JEON
;
Ji Seon OH
;
Seung Won CHOI
;
Doo Ho LIM
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. dlaengh@hanmail.net
- Publication Type:Case Report
- Keywords:
Pancreatic neoplasms;
Neuroendocrine tumors;
Arthritis;
Panniculitis
- MeSH:
Anti-Bacterial Agents;
Arthritis*;
Biopsy;
Biopsy, Needle;
Crystallization;
Diagnosis;
Hospitalization;
Humans;
Knee;
Knee Joint;
Leg;
Leukocyte Count;
Neoplasm Metastasis;
Neuroendocrine Tumors*;
Pancreatic Neoplasms;
Panniculitis*;
Skin;
Synovial Fluid
- From:Journal of Rheumatic Diseases
2017;24(5):313-317
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pancreatic neoplasm is complicated and can be preceded by extra-pancreatic manifestations, such as cutaneous and musculoskeletal symptoms. Awareness of these associations is important for timely diagnosis and appropriate treatment. We report a case of pancreatic neuroendocrine tumor (NET) presenting with arthritis and panniculitis. The patient had a two month history of right knee pain and subcutaneous nodules in both legs. Synovial fluid analysis from the right knee joint revealed a mildly increased white blood cell count without crystallization. A skin biopsy of a subcutaneous nodule revealed lobular panniculitis. The initial treatment with empirical antibiotics did not alleviate the symptoms; however, the right knee arthritis and skin nodules improved with steroid treatment. On the eighth day of hospitalization, the patient complained of abdominal discomfort. Abdominopelvic computed tomography scanning revealed a 14-cm sized pancreatic mass with peritoneal metastasis. Percutaneous needle biopsy confirmed the diagnosis of pancreatic NET.
